TRANSCRIPTIONAL AND CELLULAR DIVERSITY OF THE HUMAN HEART
The largest survey of human single nuclear transcriptomes at the time encompassing nearly 300,000 nuclei from all four chambers of seven donors. Ultimately, this work is a culmination of wonderful collaboration between academic and pharmaceutical labs to uncover novel biology. The field moves fast, and we continue to implement new approaches to improve upon this work. Read the full manuscript here and access our data at the Single Cell Portal.
MYOCYTE-SPECIFIC UPREGULATION OF ACE2 IN CARDIOVASCULAR DISEASE: IMPLICATIONS FOR SARS-COV-2-MEDIATED MYOCARDITIS
When COVID-19 struck, our lab quickly pivoted to both serve as a clinical testing laboratory for the local community hospital (MVHS) and to understand the cardiac complications associated with COVID-19 infection. Here we report on the distribution of the COVID receptor from our single nucleus sequencing data, examine changes associated with disease status, and determine the effects of anti-hypertensive medications. Read the full letter here.