PUBLICATIONS

The Genomic Decryption Lab at MMRI works hard to publish our work in leading journals. Read below for some highlights or check the link to our bibliography on PubMed for a full listing.

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SINGLE-NUCLEUS PROFILING OF HUMAN DILATED AND HYPERTROPHIC CARDIOMYOPATHY

Nature, June 22, 2022

Single nucleus RNA sequencing of late stage heart failure reveals a transcriptional convergence of differing etiologies of cardiomyopathy. Read more about molecular insights into heart failure and fibroblast activation here. Data may be found on the Single Cell Portal

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CLINICO-HISTOPATHOLOGIC AND SINGLE-NUCLEI RNA-SEQUENCING INSIGHTS INTO CARDIAC INJURY AND MICROTHROMBI IN CRITICAL COVID-19

JCI Insight January 25, 2022

Formation of microthrombi are the most prominent clinical feature of severe COVID-19 infection in the heart. We partnered with Emily Tsai, MD of Columbia University to perform single nucleus RNA sequencing on a cohort of myocardial samples with and without microthrombi. Notably, we observed a key role for fibroblast activation only within those tissue with microthrombi suggesting critical pathways for microthrombus formation and maintenance that may not be targeted with typical antithrombotics. Read the full paper in JCI Insight and find the data on the Single Cell Portal

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TRANSCRIPTIONAL AND CELLULAR DIVERSITY OF THE HUMAN HEART

August 4, 2020

The largest survey of human single nuclear transcriptomes at the time encompassing nearly 300,000 nuclei from all four chambers of seven donors. Ultimately, this work is a culmination of wonderful collaboration between academic and pharmaceutical labs to uncover novel biology. The field moves fast, and we continue to implement new approaches to improve upon this work. Read the full manuscript here and access our data at the Single Cell Portal

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MYOCYTE-SPECIFIC UPREGULATION OF ACE2 IN CARDIOVASCULAR DISEASE: IMPLICATIONS FOR SARS-COV-2-MEDIATED MYOCARDITIS

January 25, 2025

When COVID-19 struck, our lab quickly pivoted to both serve as a clinical testing laboratory for the local community hospital (MVHS) and to understand the cardiac complications associated with COVID-19 infection. Here we report on the distribution of the COVID receptor from our single nucleus sequencing data, examine changes associated with disease status, and determine the effects of anti-hypertensive medications. Read the full letter here

Pipetting Samples

OTHER PUBLICATIONS

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For a complete catalogue of our work, please see PubMed